The Great River Road takes adventure-seekers on the open road as it parallels the Mississippi River. The Great River Road in Illinois National Scenic Byway clocks in at 550 miles and is arguably the most gorgeous and picture-perfect segment of the drive. The southern segment of the National Scenic Byway passes south of East St. Louis and Collinsville down to Cairo, with cities like Cape Girardeau on the other side of the river in Missouri.
St. Louis, MO - Great River Road South, IL: 42 mins approx.
Subscribe to our mailing list
and receive our latest deal!
XImportant: Many destinations may have COVID-19 travel restrictions in place, including specific restrictions for lodging. Check any national, local, and health advisories before you book any destination.
Receive the latest deals for travel to Asia, Europe, Hawaii and Latin America.
Receive the latest deals for travel to Europe.