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Guayaquil and Cartagena by Air

6 to 9+ Nights from $1,441*
* Sample price: priced within the past 7 days for a 12/30/2025 arrival, departing Miami MIA (FL), US. Choose departure city, cabin and dates.

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This 6 night sample itinerary includes:

  • Flight into Guayaquil and out of Cartagena
  • Hotel for 3 nights in Guayaquil
  • Flight from Guayaquil to Cartagena
  • Hotel for 3 nights in Cartagena

An unforgettable getaway to these coastal cities of Ecuador and Colombia!. Discover Guayaquil (known as The Pearl of the Pacific; is one of the most important coastal town in Ecuador and main gateway to Galapagos Island); after that, catch a flight to Cartagena (colonial city on the shores of the sea. The historic walled city is famous for its castles, culture, history and colorful buildings as well as the iconic palenqueras –Afro-Colombian women in bright dresses selling fruit in Cartagena`s plazas-).

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Choose your preferred flight cabin class
Select up to 14 nights in each city during your stay
Pick from a wide selection of accommodation types (hotels, apartments, B&Bs, Guesthouses, and more)
Add transfers, activities and experiences, and more services to enhance your vacation
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Flexible Itinerary

  • Guayaquil

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  • Cartagena

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Ecuador and Galapagos
Colombia

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Trip Summary

  • Guayaquil
    Guayaquil

    Guayaquil is the largest city, the most important port in Ecuador, and the gateway to the Galapagos. The city is carved by rivers and estuaries, and is known as the 'Pearl of the Pacific'. It boasts a wonderful blend of history, nature, and tradition throughout its historic neighborhoods, parks, and monuments. Visitors will find great shopping opportunities, magnificent museums, historic monuments and sprawling parks in this exciting city.

    Visit the Simon Bolivar Malecon, La Rotonda, Parque Seminario, Santa Ana Hillside, Municipal Palace, Metropolitan Cathedral of Guayaquil, Las Penas, La Bahia and much more.

  • Cartagena
    Cartagena

    Walk through Cartagena's welcoming alleys and streets and you will discover one of the most fascinating towns in the Caribbean, with a uniquely romantic atmosphere and well-preserved colonial architectural treasures. To add to its Caribbean Sea appeal, Cartagena guards inside its walls the largest fortification in the Americas, built during Colonial times to protect it from pirates and buccaneers. Throw in the cultural mélange resulting from the Spanish-indigenous mix and you have a vibrant city that should be on every traveler's must-see list.

    Explore the Old City, Castillo de San Felipe de Barajas, Street Food Tour, Visit a Mud Volcano, Islas del Rosario, Mercado de Bazurto, Playa Blanca, Convento De La Popa, and so much more!

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