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Quito - Cuenca - Guayaquil - Santa Cruz Island - Isabela Island

10 Nights from $1,962*
* Sample price: priced within the past 7 days for a 11/6/2026 arrival, departing Miami MIA (FL), US. Choose departure city, cabin and dates.

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This 10 night sample itinerary price includes:

  • Flight into Quito and out of Guayaquil
  • Hotel for 2 nights in Quito
  • Flight from Quito to Cuenca
  • Hotel for 2 nights in Cuenca
  • Flight from Cuenca to Guayaquil
  • Hotel for 1 night in Guayaquil
  • Flight Guayaquil to Santa Cruz Island
  • Hotel for 2 nights in Santa Cruz Island
  • Transfer + Public speedboat to Isabela Island
  • Hotel for 2 nights in Isabela Island
  • Transfer + Public speedboat to Baltra Airport
  • Flight from Baltra Airport (Santa Cruz Island) to Guayaquil
  • Hotel for 1 night in Guayaquil

Combine the best of Colonial Heritage with amazing nature and wildlife! Start your journey at Quito, the capital city of Ecuador and place of the exactly the Middle of the World. Then take a flight to Cuenca, after Quito, Cuenca is Ecuador’s most important and beautiful colonial city. You will then head to Guayaquil, the main port of the Ecuador and the most populous city in the country. Up next take your flight to Santa Cruz Island, the second largest island of the Galapagos and the most populated urban center in the islands. After enjoying the main island, take the public speedboat to Isabela Island, famous for its geology but also provides an interesting display of fauna and flora. Lastly, take your flight to Guayaquil, to later take your flight home.

What Makes Tripmasters Vacation Packages Different?
Unique, fully custom approach to vacation planning
Choose your preferred flight cabin class
Select up to 14 nights in each city during your stay
Pick from a wide selection of accommodation types (hotels, apartments, B&Bs, Guesthouses, and more)
Add transfers, activities and experiences, and more services to enhance your vacation
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Ecuador and Galapagos

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