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Panama City and Cartagena by Air

4.7 out of 5 stars
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6 to 9+ Nights from $439*
* This sample price: priced within the past 7 days for check-in on 1/28/2025. Choose your own arrival dates.

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This 6 night sample itinerary includes:

  • Hotel for 3 nights in Panama City
  • Flight from Panama City to Cartagena
  • Hotel for 3 nights in Cartagena

Discover the treasures of Colombia and Panama!. Visit Panama City (most attractive Capital City and a curious blend of old Spain, modern America and the bazaar atmosphere of the East. The city is a regional hub for trading. It is best known for The Panama Canal and its charming Casco Viejo. This lively Latin American city also borders one of Central America's richest rain forest). After that, catch a flight to Cartagena (colonial city on the shores of the sea, and one of the most visited cities. The historic walled city remains alongside the ultramodern skyscraper-filled Bocagrande. Cartagena is famous for its castles, culture, history and colorful buildings as well as the iconic palenqueras –Afro-Colombian women in bright dresses selling fruit in Cartagena`s plazas-). This is a flexible vacation package. Select your number of nights in each city, desired hotel and activities.

Flexible Itinerary

  • Panama City - Canal

  • Cartagena

Customer Reviews

4.7 out of 5 stars

Trip Summary

  • Panama City - Canal

    Panama City, known to many as the home of the Panama Canal, is just a stone's throw from some of some Central America's richest rain forests, and complex ecosystems. Modern-day Panama City is formed by the equivalent of three self-contained cities that are historically, architecturally, and in some ways culturally distinct. There is the modern city with the huge skyscrapers housing many financial institutions, the Colonial-era 'Casco Viejo', and 'Panama Viejo' with the remnants of the original colonial city, the first in the Americas on the Pacific coast.

    Visit the Panama Canal, Panama Viejo, Casco Viejo, Miraflores, Causeway Islands, Metropolitan Natural Park, Bridge of the Americas, Biomuseo, Amador Causeway, and so much more!

  • Cartagena

    Walk through Cartagena's welcoming alleys and streets and you will discover one of the most fascinating towns in the Caribbean, with a uniquely romantic atmosphere and well-preserved colonial architectural treasures. To add to its Caribbean Sea appeal, Cartagena guards inside its walls the largest fortification in the Americas, built during Colonial times to protect it from pirates and buccaneers. Throw in the cultural mélange resulting from the Spanish-indigenous mix and you have a vibrant city that should be on every traveler's must-see list.

    Explore the Old City, Castillo de San Felipe de Barajas, Street Food Tour, Visit a Mud Volcano, Islas del Rosario, Mercado de Bazurto, Playa Blanca, Convento De La Popa, and so much more!

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