Route 66 - Central Vacation Packages
The central portion of Route 66, the USA`s `Mother Road`, takes travelers through the states of Texas, New Mexico, and Arizona, and covers 1,074 miles of the 2,448-mile journey. You will be able to explore small towns (even a ghost town or two!), some of the most beautiful and solitary stretches of the drive, national parks like the Grand Canyon and the Petrified Forest, and big cities such as Amarillo, Albuquerque, and Flagstaff.
Best Vacation Packages:
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7 nights from $1,343*More details›
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8 nights from $1,222*More details›
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Major Cities and Parks
Sections of Route 66
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The Eastern portion of Route 66 takes you through the Midwest, starting in Chicago and meandering through Illinois, Missouri, Kansas, and Oklahoma.
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The westernmost portion of Route 66 takes you through the Golden State of California to the end of the line in Santa Monica, passing through cities like Los Angeles along the way.
More to Explore
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The West Coast
Experience an unforgettable vacation exploring the fantastic Pacific West Coast Region including Washington, Oregon, and California along with the awe-inspiring charms of Alaska.
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The Rocky Mountains
The Rocky Mountains stretch some 3,000 miles from British Columbia and Alberta in Canada through Idaho, Montana, Wyoming, Colorado, and down to New Mexico in the U.S.
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The Southwest
The sprawling region of The Southwest of the United States encompasses four large states; Arizona, New Mexico, Oklahoma, and Texas. Home to spectacular natural wonders such as the Grand Canyon and Monument Valley spread throughout miles of wide-open spaces and varied terrains.
SUGGESTED ITINERARIES
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Route 66 - Amarillo - Santa Fe - Albuquerque - Flagstaff - Las Vegas - Los Angeles (Self Drive)10 nights from $1,482*› - Flight into Amarillo and out of Los Angeles
- Rental Car for 11 days
- Hotel for 2 nights in Amarillo
- Hotel for 1 night in Santa Fe
- Hotel for 2 nights in Albuquerque
- Hotel for 1 night in Flagstaff
- Hotel for 2 nights in Las Vegas
- Hotel for 2 nights in Los Angeles
Driving Time
Amarillo - Santa Fe: 4 hrs. 10 mins. approx.
Santa Fe - Albuquerque: 1 hr. approx.
Albuquerque - Flagstaff: 4 hrs. 45 mins. approx.
Flagstaff - Las Vegas: 2 hrs. 45 mins. approx.
Las Vegas - Los Angeles: 4 hrs. 10 mins. approx.-
Houston - Austin - Dallas - Amarillo - Santa Fe - Albuquerque (Self Drive)10 nights from $1,181*› - Flight into Houston and out of Albuquerque
- Rental Car for 10 days
- Hotel for 2 nights in Houston
- Hotel for 2 nights in Austin
- Hotel for 2 nights in Dallas
- Hotel for 1 nights in Amarillo
- Hotel for 1 nights in Santa Fe
- Hotel for 2 nights in Albuquerque
Driving Time
Houston–Austin: 2hr 32 min approx.
Austin –Dallas: 2hr 56 min approx.
Dallas – Amarillo: 5 hrs 29 mins approx.
Amarillo– Santa Fe: 4 hrs 7 mins approx.
Santa Fe– Albuquerque: 1 hr approx.-
Phoenix - Sedona - Santa Fe - Albuquerque (Self Drive)7 nights from $1,049*› - Flight into Phoenix and out of Albuquerque
- Rental Car for 8 days
- Hotel for 2 nights in Phoenix
- Hotel for 2 nights in Sedona
- Hotel for 1 night in Santa Fe
- Hotel for 2 nights in Albuquerque
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Route 66 Origins Self Drive (Chicago - Springfield - St Louis - Tulsa - Oklahoma City - Amarillo)15 nights from $2,039*› - Flight into Chicago and out of Amarillo
- Rental Car for 13 days
- Hotel for 3 nights in Chicago
- Hotel for 2 nights in Springfield, IL
- Hotel for 2 nights in St. Louis
- Hotel for 2 nights in Springfield, MO
- Hotel for 2 nights in Tulsa
- Hotel for 2 nights in Oklahoma City
- Hotel for 2 nights in Amarillo
Driving Time
Chicago– Springfield, IL: 3 hrs. 14mins. approx.
Springfield, IL- St. Louis: 1 hr. 28 mins. approx.
St. Louis- Springfield, MO: 3 hrs. 22 mins. approx.
Springfield, MO- Tulsa: 3 hrs approx.
Tulsa - Oklahoma City: 1 hr 34 mins. approx.
Oklahoma City - Amarillo: 4 hrs. approx.
Flexible Itinerary: Personalize your hotels, transportation, and length of stay in each city while enjoying included, curated activities that enhance your experience!
What Makes Tripmasters Vacation Packages Different?
Unique, fully custom approach to vacation planning
Choose your preferred flight cabin class
Select up to 14 nights in each city during your stay
Pick from a wide selection of accommodation types (hotels, apartments, B&Bs, Guesthouses, and more)
Add transfers, activities and experiences, and more services to enhance your vacation
Live phone and chat support
Fully Flexible Itinerary: Personalize your hotels, transportation, and length of stay in each city. Easily add curated experiences to complete your journey.
Flexible Itinerary: Personalize your hotels, transportation, and length of stay in each city while enjoying included, curated activities that enhance your experience!
Interests
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The United States boasts 62 protected National Parks spread throughout 29 states covering approximately 52.2 million acres of land. To be classed as a National Park these natural areas must provide an outstanding region of beauty, an unusual ecosystem, or a plethora of recreational activities.
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Escape to dramatic desert destinations where luxurious resorts and spas are nestled beside fiery rock formations and acres of sprawling landscapes. There are many mystical and majestic desert towns found on the West coast of the USA steeped in history and offering plenty of activities and adventures.
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The Colorado Rockies are known for epic skiing trips, boasting powdery white slopes that offer endless hours of outdoor fun. Escape to the mountains for a wonderful vacation where some of the best ski resorts in the country are found.
USA Customer Reviews
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Overall, my experience, the trip masters was good, but but I had a problem you couldn’t help. The reason I say this is that we had a problem with a ho ...Traveled on: 9/24/2026
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The hotel in Washington DC was very small and the bathroom offered little space and privacy. However, the hotel was eccentric and had fun decorations. ...Traveled on: 8/24/2026
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You guys are great! Keep being awesome ...Traveled on: 6/12/2026
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It was an excellent trip ...Traveled on: 6/5/2026
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I liked the car rental, hotels, flights, and locations. It was quite an adventure! It would have been nice to know of the one-way car rental fee more ...Traveled on: 3/29/2026














