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St Louis - South Great River Road - Memphis (Self Drive)

7 Nights from $1,066*
* Sample price: priced within the past 7 days for a 5/25/2026 arrival, departing Miami MIA (FL), US. Choose departure city, cabin and dates.

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This 7 night sample itinerary includes:

  • Flight into St. Louis and out of Memphis
  • Rental Car for 8 days
  • Hotel for 3 nights in St. Louis, MO
  • Hotel for 2 nights in Great River Road South, IL
  • Hotel for 2 nights in Memphis, TN
  • Driving Time
    St. Louis, MO - Great River Road South, IL: 42 mins. approx.

The Great River Road is a collection of state and local roads that follow the course of the Mississippi River through ten states. Start this trip in Missouri visiting St. Louis (a major city in Missouri along the Mississippi River, known for the Gateway Arch, the tallest monument constructed in the United States). After that, drive to Illinois, to reach Great River Road South Area (with its 550-mile route on Illinois' western border offers breathtaking views and majestic landscapes that inspire and soothe the soul) and lastly, in Tennessee, enjoy Memphis (one of the more historic and culturally significant cities, home of blues and rock and roll).

What Makes Tripmasters Vacation Packages Different?
Unique, fully custom approach to vacation planning
Choose your preferred flight cabin class
Select up to 14 nights in each city during your stay
Pick from a wide selection of accommodation types (hotels, apartments, B&Bs, Guesthouses, and more)
Add transfers, activities and experiences, and more services to enhance your vacation
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