Great River Road South, IL Vacation Packages
The Great River Road takes adventure-seekers on the open road as it parallels the Mississippi River. The Great River Road in Illinois National Scenic Byway clocks in at 550 miles and is arguably the most gorgeous and picture-perfect segment of the drive. The southern segment of the National Scenic Byway passes south of East St. Louis and Collinsville down to Cairo, with cities like Cape Girardeau on the other side of the river in Missouri.
Best Great River Road South, IL Vacation Packages:
St Louis - South Great River Road - Memphis (Self Drive)
7 nights from $1,062*
The Great River Road is a collection of state and local roads that follow the course of the Mississippi River through ten states. Start this trip in Missouri visiting St. Louis (a major city in Missouri along the Mississippi River, known for the Gateway Arch, the tallest monument constructed in the United States). After that, drive to Illinois, to reach Great River Road South Area (with its 550-mile route on Illinois' western border offers breathtaking views and majestic landscapes that inspire and soothe the soul) and lastly, in Tennessee, enjoy Memphis (one of the more historic and culturally significant cities, home of blues and rock and roll).
Fully Flexible Itinerary: Personalize your hotels, transportation, and length of stay in each city. Easily add curated experiences to complete your journey.
Other Great River Road South, IL Vacation Packages:
Map of the Great River Road (Southern Illinois)
Hotels and Activities
SUGGESTED Great River Road South, IL VACATION PACKAGES:
USA Customer Reviews
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Overall, my experience, the trip masters was good, but but I had a problem you couldn’t help. The reason I say this is that we had a problem with a ho ...Traveled on:9/24/2026
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The hotel in Washington DC was very small and the bathroom offered little space and privacy. However, the hotel was eccentric and had fun decorations. ...Traveled on:8/24/2026
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You guys are great! Keep being awesome ...Traveled on:6/12/2026
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It was an excellent trip ...Traveled on:6/5/2026
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I liked the car rental, hotels, flights, and locations. It was quite an adventure! It would have been nice to know of the one-way car rental fee more ...Traveled on:3/29/2026
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